HEREDITARY BREAST CANCER

CAUSES OF HEREDITATIVE BREAST CANCER:

It occurs as a result of mutation (disorder) in the BRCA-1 and BRCA-2 genes. interest. Breast cancers that develop as a result of such a genetic disorder constitute approximately 10% of all breast cancers. Hereditary breast cancers may have characteristics such as appearing at a young age (before menopause), developing cancer in both breasts, and developing ovarian cancer along with breast cancer.

BRCA- While the risk of developing breast cancer in women with mutation in the 1 gene is 85% and the risk of ovarian cancer is 45%, in those with BRCA-2 gene mutation, the risk of breast cancer is 84% and the risk of ovarian cancer is 76%. These rates increase even more if there is a mutation in both of them.

HOW TO DIAGNOSE:

BRCA-1 and BRCA-2mutation is diagnosed by genetic testing.

WHO SHOULD HAVE BRCA-1 and BRCA-2 TESTED:

If two people from first degree(mother, sister, daughter) relatives have breast cancer and one of them got sick under the age of 50

From first or second degree relatives (grandmother, aunt, aunt) if three or more of you have breast cancer

If you have a relative in your family who has both breast and ovarian cancer

If your first-degree relative has cancer in both breasts

If there is male breast cancer in your family

In this case, genetic counseling is required regarding which genetic tests should be performed.

BRCA-1 and PRECAUTIONS TO BE TAKEN IN THOSE WITH BRCA-2 DISORDER:

Drug protection: The use of estrogen-suppressing drugs such as tamoxifen or raloxifene reduces the risk of developing breast cancer by 50%

Preventive surgical procedures: The risk of breast cancer can be reduced by 95% by surgery performed by protecting the bilateral skin of the breasts, evacuating the breast tissue inside and placing a silicone prosthesis in the same session. It is also recommended to remove bilateral ovaries in pre-menopausal patients.

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