The most common cause of pregnancy losses observed in the first three months of pregnancy is the abnormal number of chromosomes in developing embryos.
What are the Factors Affecting Pregnancy Results After Transfer of a Chromosomally Healthy Embryo Obtained by PGT-A Method?
Nowadays, PGT-A method, also known as preimplantation genetic diagnosis, is applied for many different indications such as advanced maternal age, severe male factor, recurrent in vitro fertilization failures and recurrent pregnancy loss.
The most common cause of pregnancy loss in the first three months of pregnancy is the abnormal number of chromosomes in the developing embryos. After investigating all the anatomical, hormonal and metabolic reasons that may cause this situation, especially in couples with a history of recurrent pregnancy loss, the transfer of a chromosomally healthy embryo obtained by the PGT-A method has become one of the frequently applied methods in these couples.
However, after the transfer of an embryo obtained with this method, which we use to prevent pregnancy losses due to chromosome number or structural disorders in the embryos, it is still possible to fail to achieve pregnancy or to lose the resulting pregnancy.
Additionally; Factors such as high body mass index, the presence of endometriosis and adenomyosis conditions known as chocolate cyst disease, the type of endometrial preparation process for frozen embryo transfer, the quality of the transferred embryo and the occurrence of unequal cell divisions during embryo development are factors that affect a chromosomally healthy embryo transfer. It has been observed that it increases the risk of pregnancy loss, even if it is carried out. in the light; Factors that affect the success of pregnancy after the transfer of an euploid embryo, that is, a normal number of chromosomes, should be examined in detail, such as embryo selection in cases with more than one euploid embryo, and all correctable factors related to the case itself.
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