Gynecology, Obstetrics and In Vitro Fertilization Specialist Op. Dr. Seval Taşdemir explained the applications about translocation solution and in vitro fertilization treatment for you.
Genetic factors are one of the most important causes of miscarriages. Individuals have 46 chromosomes (23 pairs) in each cell. 23 of these chromosomes come from the mother and 23 from the father. Cells contain 22 pairs of autosomal chromosomes and 1 pair of sex chromosomes. Men have one X and one Y sex chromosome, and women have two X sex chromosomes. Before fertilization, the chromosomes in the egg and sperm cells are reduced by half (23) by meiosis. With the union of the egg and sperm cell, called fertilization, an embryo containing 46 chromosomes is formed. The problems that occur during this time lead to anomalies in the number of chromosomes.
Translocation: Incorrect chromosome alignment
Another chromosomal disorder is translocation, where the chromosome number is normal but the sequence is incorrect. When a translocation occurs in the expectant mother or father, this does not cause any health problems in the expectant mother or father, but an imbalance in the distribution of genetic information may occur during egg or sperm formation. This situation is determined by the chromosomal examination to be performed on the expectant mother and father.
If the mother or father is a balanced translocation carrier, the child will suffer from a certain degree of physical disability and learning disabilities, depending on the type of chromosomes involved and exactly how much chromosome material is missing or excessive.
Couples who have had two or more miscarriages can find out whether they are translocation carriers by having a chromosome test. Whether a person is a translocation carrier or not can be determined with a simple blood test. Translocation is inherited from the mother or father or occurs at fertilization. The translocation cannot be corrected and persists throughout life. Balanced translocation carriers can have healthy children.
This situation can be controlled with in vitro fertilization treatment
The child born to a mother or father who is a translocation carrier may be completely healthy, or as a result of an unbalanced translocation. He may also be disabled. When pregnancy occurs naturally, the health of the child is left entirely to chance. However, in vitro fertilization treatment Embryos created by applying visi are examined with PGT (Preimplantation Genetic Testing). Healthy embryos are selected and transferred. In this way, couples can be enabled to have healthy children.
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