Receptors are protein structures found inside and on the surface of cells. Hormones or similar molecules bind to these receptors and send signals to the cell for growth and proliferation, and as a result of these signals, the cells multiply.
Normal breast tissue cells also have receptors that cause the cells to proliferate. The most well-known of these are hormone receptors (estrogen, progesterone) and HER-2 receptors. These receptors bind to some molecules and create signals for the cell to grow and multiply.
These receptors we mentioned are also found in breast cancer cells, and they cause the cancer cell to grow and multiply rapidly. Fortunately, there are treatments for these receptors that block them, and thanks to these treatments, it is easier for us to control the cancer.
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Some cancer patients do not have the estrogen, progesterone and HER-2 receptors we mentioned, and are reported as "triple negative" in pathology test results.
In triple negative breast cancers. Hormone therapy (tamoxifen etc.) and targeted therapies (such as Herceptin) are not useful. Different treatment protocols are applied to these patients.
Triple negative breast cancer accounts for 10-20% of all breast cancers.
Features of triple negative breast cancer
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They are more aggressive than other breast cancers and their prognosis is worse, They are more likely to recur.
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They are generally poorly differentiated, Grade 3 cancers and are more aggressive.
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The type of cancer cells is "basal-like" " is.
Who gets type-negative breast cancer?
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It is more common in young patients, patients are usually under the age of 50
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It is more common in black and Hispanic people
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It is more common in those with BRCA1 mutation. It is common, 70% of those with BRCA 1 mutation are triple negative.
There are different treatment protocols for triple-negative breast cancers.
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