WHAT IS CHORIONOUS VILLUS BIOPSY?
Chorionic villus biopsy is one of the prenatal diagnosis methods. 10-13. It is done during pregnancy weeks. It is a method used to diagnose genetic diseases and chromosomal anomalies in the baby. It has the advantage of providing early diagnosis and more
examination samples. However, since a piece of tissue (chorionic
villus) is taken from the baby's partner (placenta), the risk of miscarriage is higher than the prenatal diagnosis method performed in the following weeks.
WHO IS IT RECOMMENDED?
1. Prenatal screening If the test results are positive: To clarify the diagnosis if the result of the screening test (first trimester screening,
free fetal DNA in the mother's blood) is worrisome or high risk.
2. If there was a chromosomal disorder in the previous pregnancy: If you had Down syndrome in your previous pregnancies If a baby with
or another chromosomal anomaly is detected, the risk in this pregnancy is also high.
3. Advanced maternal age: Diagnostic tests are now offered as an option to all pregnant women, but the risk of a baby with a chromosomal disorder increases with
maternal age. .
4. If you or your partner have a known family history of a genetic disease, or if you or your
partner is a carrier for a known genetic disease: a monogenic disease as well as chromosome number
disorders or structure disorders, such as Down syndrome It is also used for diagnosis.
WHAT ARE THE RISKS?
Low risk is about 1%. If the baby is smaller than expected, the risk increases, because developmental delay is common in babies with chromosomal disorders.
Infection: Although intrauterine infection is very rare, there is a theoretical risk.
Limb deformity: In some old studies, this Although the risk is mentioned, it is possible for applications
less than 10 weeks, but it is no longer performed in these weeks.
WHAT TO BE CONSIDERED?
You should not force yourself after the procedure. If possible, have someone else drive you home. Intercourse is prohibited for one
week. Strenuous and tiring activities that will increase intra-abdominal pressure should not be done for three days. Although plane travel is not risky, it is not recommended if a problem occurs, as it is preferred to be close to home.
Mild cramp-like groin pain is normal for the first day or two. Severe cramp-like pain in the groin, bleeding, water breaking and temperature >38 o C If you have any problems, you should consult your doctor urgently. If you have severe cramp-like pain in the groin,
bleeding, water breaking, fever >38 o C, you should consult your emergency doctor.
HOW WILL I DECIDE?
There is no 'one right decision'. Acceptable risks are different for each couple, and different couples may make different decisions in the same situation. Some couples do not want the procedure
due to the risk of miscarriage if their pregnancy management will not change. Some conditions can be treated during pregnancy. Amniocentesis may be preferred to detect these situations.
HOW WILL I DECIDE? According to the results, they will organize their lives, prepare themselves psychologically, and, if necessary, organize a birth in a certain center. Some couples clearly do not want the pregnancy to continue in case of a negative result. Some couples accept the procedure even if they do not know how to decide.
Screening tests and diagnostic tests should be offered as options to all pregnant women. You should discuss the pros and cons of these
approaches with your doctor. Ultimately, it's up to you to decide. Most people get the
screening test first. He acts according to the result. Some pregnant women do not have any tests. Some pregnant women require a direct
diagnostic test. This group knows that they are at high risk for a chromosomal problem or condition that cannot be detected by a screening test. She wants to learn everything possible about the baby's condition in advance
and takes the risk of miscarriage.
If you choose to do a screening test first, you should inform your doctor if the result of the test is risky.
You should make the decision. You should evaluate which diagnostic test can be performed according to the week of pregnancy, the pros and cons of the procedures, and the risk of loss.
HOW IS IT DONE?
It is performed under outpatient clinic conditions. It is desirable that the bladder be full. The baby's gestational age and placental location are determined by ultrasound in the supine position. The placenta is reached with a suitable needle accompanied by ultrasound. Placental tissue is removed with negative pressure using a special device. The procedure can be performed from the abdomen (transabdominal)
or through the cervix (transcervical).
TRANS ABDOMINAL METHOD
Frequently� Usually local anesthesia is applied to the passage area of the needle. The abdominal skin is cleaned with an antiseptic. The anterior abdominal wall and the uterine wall are passed with a special, long, thin needle. During this time, first a stinging sensation and then cramp
may be felt. Placental tissue is removed with a syringe by applying negative pressure. The procedure is terminated by removing the needle.
TRANSSERVICAL METHOD
It is not widely used in our country's practice.
WHEN WILL THE RESULTS BE AVAILABLE?
Results appear in 1-2 weeks. 46 pairs of chromosomes and sex chromosomes are examined in terms of structure and number.
1% false positive results occur due to 'placental mosaicism'. In this case, the baby's
genetic structure should be clarified through amniocentesis.
HOW TO TAKE CARE IF THERE IS A PROBLEM?
Genetic counseling is sought. You will be given more information about the situation and your options will be discussed. Whatever your decision
is, it is beneficial to get psychological counseling.
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