Olive leaf

Although the olive leaf has made its name due to the covid pandemic, it has been used for therapeutic purposes since ancient times, especially in the regions where it grows. Today, thanks to the developing technology, medicine and science, studies have shown that the olive leaf has many bioactivity. Oleuropein is the molecule with the most important biological activity that enables olive leaf to be used in the treatment of disease.

Although oleupein was first detected in 1908, its structure was defined in 1960. Oleuropein is found in the tree, leaf, bud, wood and bark of olives. This substance, which is found in excess in the early stages of the olive fruit, is metabolized with ripening and its amount decreases, and it is also the substance that gives the bitter taste to the fruit. Since oleuropein is high in unprocessed olives and leaves, bitterness is also high. Since hydroxytyrosol, the metabolized product of oleuropein, is found more in processed olives and olive oil, bitterness is also reduced. In addition, oleuropein protects the plant from harmful microorganisms and diseases and contributes to the longevity and durability of the tree.

Oleuropein cannot be used directly in the human body. It can be absorbed after being digested in the digestive system. It is completely divided into hydrocytocele and its subunits and is not found in human plasma and feces.

I would like to mention the studies on olive leaf and oleuropein and give information about its field of activity:

There are many studies on the blood sugar-lowering effect of olive leaf and its effect on individuals with diabetes. This blood-lowering effect; It is thought to do so by affecting insulin secretion and increasing peripheral glucose uptake. However, there is not enough information about the exact mechanism of action and the ideal dose.

In a study conducted in 2012, olive leaf was applied to 79 patients with type 2 diabetes for 14 weeks. It has been determined that it significantly reduces HbA1c and fasting insulin values.

In another study conducted in 2006, rabbits with diabetes were given 20 mg/kg oleuropein daily for 16 weeks. Oxidative, which regulates blood glucose levels and is also produced by diabetes It has also been shown to reduce stress-related damage.

In a study in which olive leaf extract was given orally to diabetic rats for 4 weeks, a significant decrease was observed in serum glucose and cholesterol levels.

In 2010, In a study conducted in rats, it was observed that the compounds in the olive leaf improved hepatic values ​​and reduced oxidative stress and inflammation.

In a study examining the glycemic response to rice loading in humans, it was stated that olive leaf extract significantly reduced blood glucose level compared to the control group and oleuropein accelerated glucose uptake into cells. . Studies have shown that the antioxidants in olive leaves can be effective in the treatment of cancers such as liver, breast and prostate. In the literature, it is stated that oleuropein extracts may be effective in inhibiting the proliferation of human breast adenocarcinoma cells (MCF-7) and human bladder cancer cells (T-24). It can increase the arrhythmia and prevent intestinal muscle spasms. It is also known to have a preventive effect on heart diseases and myocardial infarction by regulating blood coagulation and blood circulation. In addition, it has been shown to be effective in preventing cardiovascular diseases and regulating blood pressure by preventing LDL oxidation. In addition, it has been shown that phenolic compounds in olive leaves prevent the formation of intravascular plaque and provide a significant decrease in blood glucose levels in individuals. However, there is not enough information about the mechanism of action. *

It has been reported that tea prepared from olive leaves has an antioxidant effect against DPPH and hydrogen peroxide radicals. Olive leaf protects the body from active free radicals. It contains antioxidant properties that help ruma.*

In a study conducted in 2006, it was concluded that oleuropein supports immunity by increasing phagocytosis. In another study conducted in 2018, oleuropein increased the total lymphocyte count and was effective in regulating the human peripheral immune response.

It is thought to help prevent Alzheimer's disease. It is also thought to have a neuroprotective effect.

Oleuropein shows natural antimicrobial properties. There are studies showing that it delays and inhibits the growth rate of microorganisms. In many studies on this subject, the phenolic glycoside oleuropein and its degradation products Bacillus cereus, Enterococcus faecalis, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Lactobacillus plantarum, Moraxella catarrhalis, Pseudomonas fragi, Salmonella enterococcus faecalis, Escherichia coli, Stamonella paraphylococcus lyticus, It is claimed to have an inhibitory effect on Vibrio cholerae, Vibrio alginolyticus and molds. It was stated that the 1% extract was effective on Candida albicans in 24 hours, the 0.6% extract destroyed E. coli in three hours, and based on these findings, the antimicrobial effect of olive leaf was high. p>

To summarize;

Potential health benefits of oleuropein;*

• Antimicrobial ( Preventing the growth of microorganisms)

• Antioxidative (Preventing damaging molecules called free radicals in our cells)

• Antiatherogenic (preventing the clogging of blood vessels)

• High antioxidant potential

• Hypotensive activity (Blood pressure lowering)

• Anti-inflammatory effect (by inhibiting 5-lipoxygenase enzyme)

• Cardiopropective (LDL oxidation inhibition and platelet-blood cell aggregation)

• Hypoglycemic (Blood sugar lowering)

• Antihypertensive (Vasodilatator- lowering hypertension)

• Antiviral (effective against HIV virus)

• Stostatic (against McCoy cells)

• Mollucicidal (Toxic effect against snails)

• Endocrinal-hormonal

• Enzyme modulator

Potential benefits of hydroxytyrosol; *

(Hydroxytyrosol is a catechol byproduct of oleuropein. As olive leaves or olives mature or are processed or stored, the amount of oleuropein in their composition decreases while the amount of hydroxytyrosol increases. Absorption of hydroxytyrosol is by passive diffusion It is completely absorbed through the intestines.)

• Antimicrobial

• Antioxidative

• Human Protecting erythrocytes against oxidative damage

• Causes cytochrome C-dependent apoptosis-cell death

• Inhibits the growth of tumor cells

Olive leaf extract; It is available in different forms as concentrated liquid, powder, capsule and dry leaf tea. There is evidence supporting the potential beneficial effects of olive leaves on human health and the bioactive components (especially oleuropein) in these effects. Dried olive leaf tea is recommended for diabetics. Olive leaf tea; Although it is thought to be effective in the treatment of some complex diseases such as diabetes, cardiovascular disorders, viral and microbial infections, it has been emphasized that more studies should be done especially for its other effects.

Although the health effects of olive leaves in humans are promising, the bioactive components of olive leaves There is a need to better understand the possible interactions between In addition, there is no clear information about how much the ideal dose should be to achieve these beneficial effects in humans. Studies have shown that certain doses should be increased to obtain optimal benefits. However, studies also show that high doses of oleuropein can have a negative effect.

How to use olive leaf/tea, how much should it be consumed?

The use of olive leaf alone or in combination in tea mixture preparations is appropriate. In the form of infusion; It is prepared by brewing 7-8 g of leaves with 150 ml of hot water and drunk 3-4 times a day. Olive leaf extract can be used as 580 mg capsules per day. It is not recommended to be used for more than two months. It does not cause any side effects when used appropriately at therapeutic dose. do it. The effectiveness is higher in dry leaves.

What can olive leaf tea do, what are its potential benefits?

• Supports the immune system.

• It has the effect of lowering blood sugar.

• It has the effect of lowering high cholesterol.

• Has a blood pressure lowering effect.

• Has a positive effect on heart health.

• Cold It is good for the common cold.

• Although there is no clear data that it is effective against coronavirus, it is known that it can be effective against viruses.

• Feeling of fullness It can reduce the desire to eat by giving it.

• Supports rapid healing of wounds.

• Helps in the elimination of free radicals.

• It can be effective in delaying and inhibiting the growth rate of microorganisms.

• It can support the relaxation of the digestive system.

• It has an anti-inflammatory effect.

Can anyone consume olive leaf/tea?

 Since it can trigger colic in patients with gallstones when taken internally, its use

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