It has been clinically shown that the duration of effect increases as wrinkle treatment injections are performed at regular intervals.
Botulinum A toxin injections are the most frequently performed cosmetic procedure in the USA. The first
use on humans was by Dr. Alan Scott in 1980 in the field of strabismus treatment and blepharospasm.
The first studies on its use for wrinkle treatment were published by Carruthers et all in 1992.
The first area they applied it to was between the eyebrows.
Wrinkle Treatment Görkem Çalışkan
WRINKLE TREATMENT MECHANISM OF ACTION
The toxin consists of 97 kDa (heavy chain) and 52 kDa (light chain) consisting of 1295 amino acids. It is composed of chains connected by
disulfide bonds.
The heavy chain binds to the membrane of nerve cells, allowing the light chain to pass into the cell fluid, and the light chain binds the protein called SNAP-25, which causes the formation of acetylcholine vesicles. It prevents it from being transported
into the cell. As a result, neurotransmitter release into the synaptic gap does not occur and presynaptic neural block
occurs.
Wrinkle treatment; It does not directly affect the injected skin, it prevents the contraction of the muscle that causes wrinkles in the skin and begins to show its effect.
Clinically, it starts to have an effect on the 2nd day after wrinkle treatment and 2-4 days later. It shows its effect by reaching its maximum effect
in weeks. The beneficial effects of wrinkle treatment last for an average of 3-6 months and this period varies from person to person. It takes much longer for all effects of wrinkle treatment to disappear completely, but these
effects are not visible effects, but effects demonstrated by clinical experiments.
It has been clinically shown that the duration of effect increases as wrinkle treatment is performed at regular intervals.
Wrinkle treatment does not completely paralyze the muscles, but causes a loss of strength, and this loss of strength is sufficient for the desired cosmetic result.
The situations in which wrinkle treatment can be used are summarized as follows;
1-facial wrinkle treatment (face and upper lip)
2-hand and armpit sweating treatment (duration of effect varies between 12-14 months when done properly)
3-migraine treatment (d� �When done properly, the duration of effect varies between 10-14 months)
4-neck area wrinkle and tape treatment
5-anal fissure (there are studies showing that it has results similar to surgical treatment)
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WRINKLE TREATMENT TECHNICAL AND MEDICAL INFORMATION
The difference between an experienced wrinkle treatment injector and a technician (persons unrelated to the job, nurse, esthetician,
etc.) ends in the concept of the functional anatomy of the face. Each patient's facial structure and anatomy
are different, and the dose applied to each patient varies according to this anatomy and many other dynamics.
For this reason, when performing wrinkle treatment, the practitioner must be a plastic surgeon or a dermatologist
Be careful.
The effects of wrinkle treatment are completely temporary because the nerve cell block in the mechanism of action returns to normal
over time. The effects of wrinkle treatment vary from person to person and last for an average of 3-6 months.
When wrinkle treatment is performed at regular intervals and in the doses it deserves, it shows a summation effect and provides a much better appearance and recovery each time. It is not right to expect any benefit from wrinkle treatment, which is carried out at very low prices (often
less than the bottle cost of wrinkle treatment) due to commercial concerns, and it is a waste of money and time for patients.
When considered, wrinkle treatment should be done twice a year. Between having it done properly twice and feeling the need to have it done 4-5 times a year without knowing how much dose
is given at very low prices, not only is there a loss of time and money
but also the destruction of the ability of wrinkle treatment to treat wrinkles on the face
/> is quite worrying for plastic surgeons.
FORHEAD AREA WRINKLE TREATMENT AND EYEBROW LIFT WITH WRINKLE TREATMENT
There are two muscles in the forehead area called frontalis that help lift the eyebrows up. has. And
wrinkle treatment injections can be made into these muscles to reduce wrinkles in the forehead area and lift the eyebrows. Eyebrow lift with wrinkle treatment can be performed safely up to 6 mm. To put it simply
An injection is made into the muscles that lower the legs. Applying too much wrinkle treatment to the middle part of the forehead
will cause a MrSpock-looking eyebrow structure and also causes an increase in wrinkles on the
eyebrow.
To maximize the eyebrow lifting process with wrinkle treatment, By injecting the forehead muscle parts that are not responsible for lifting (i.e. the outer areas of the eyebrows), the eyebrows are lifted by pulling the parts that lift the eyebrows higher. However, if we also want the forehead
wrinkles to be corrected, then the eyebrows will not lift to the desired extent because injections are made to the areas above the eyebrows to eliminate the forehead
wrinkles. In order to lift the outer parts of the eyebrows, a careful examination is required and for this, your doctor will ask you to laugh repeatedly
and in the meantime, he will decide whether the ends of the eyebrows can be lifted or not. There are no fixed points for raising the eyebrows; these points vary depending on the anatomy of each patient. For this
reason, an effective examination before the application is essential.
Since the forehead area is the most visible area in the treatment of facial wrinkles, an effective wrinkle treatment
will make you look younger.
GLABELLA WRINKLE TREATMENT APPLICATION
After the muscles that cause wrinkles between the eyebrows are determined by the specialist, the application is made according to the type of wrinkle. While some patients develop vertical wrinkles when they frown, some patients develop horizontal
wrinkles, and wrinkle treatment injection points vary depending on this wrinkle type. For this
reason, although wrinkle treatment may seem like an easy procedure, knowing its basis and anatomy is absolutely necessary for the patient
for maximum results. Basically, the use of wrinkle treatment
in the treatment of facial wrinkles is especially important for the area between the eyebrows.
CROWS' FEET AND WRINKLE TREATMENT APPLICATIONS AROUND THE EYE
Crow's feet are contractions of the orbicularis oculi muscle located on the outside of the eye. It is formed as a result and this
muscle forms a round muscle along the eyeball. truck. Applying wrinkle treatment to certain parts of this muscle leads to different
effects.
For wrinkles around the eyes, the application is applied to the outer part in 3-4 points, while for wrinkles under the eyes, wrinkle treatment is not applied to every
patient. Applying uncontrolled wrinkle treatment to the lower eyelid area
may cause double vision, blurred vision and shrinkage in the lower eyelid. For this reason, after each patient is examined
in detail, it is decided whether wrinkle treatment will be performed on the lower eyelid.
After the crow's feet wrinkle treatment application, the tips of the eyebrows are lifted and this is what many patients
want. This is. However, as previously explained in the eyebrow lifting section, in some patients, this muscle is not the muscle that lifts the tip of the eyebrow. For this reason, the tip of the eyebrow may not lift in some patients.
Similarly, when wrinkle treatment is applied to crow's feet, it is in the lower eyelid section. It is felt that wrinkles
have increased, this is not an illusion but reality. The reason is that although the eye muscles on the side are weakened, the lower eyelid muscles are not weakened. In order to prevent this image, a small amount of application is applied to the lower eyelid, depending on experience. If too much, double vision is blurred. Complaints such as etc. may occur. For this reason, patients should be informed about this issue before the application.
PREPARATION OF WRINKLE TREATMENT
Botilinum A is a quickly degradable but very powerful toxin. It is dried and stored as a frozen crystal complex. During the production process, the toxin is immediately frozen at -5 oC or lower temperatures.
The toxin is diluted immediately before injection. From current experience, a dilution of 2.5 U/ml is most appropriate. It is recommended by some practitioners to freeze and store diluted but unused toxin. However, even factors such as preservatives contained in the toxin, alcohol used for cleaning, and rapid and turbulent dilution may be sufficient to denature the molecule.
After the toxin is prepared, it should be used as quickly as possible. . Although it is recommended to use it within 4 hours after reconstitution, many users freeze it and use it even within 30 days (18). However, its effect decreases, especially
48 hours after dilution. However, the best way to preserve the toxin is by freezing
. Although early practitioners and researchers stated that 10-20 U would be sufficient for each area, even 2.5 U may be effective depending on the area applied. Performing the procedure in low doses and small volumes reduces side
effects. Even doses lower than 2.5 U / 0.1 ml can be effective. However, the muscle weakening
effect is shorter lasting. Patients with large and hypertrophic muscles may require higher doses. The medicine should be prepared in a 1
ml syringe and with 18 G needles, and should also be administered with a 30 G needle.
There are two commercial types of wrinkle treatment
within the borders of the Republic of Turkey, licensed by the Ministry of Health. . One is ALLERGAN BOTOX and the other is DYSPORT. Both of them can easily be used for cosmetic purposes
but their preparations are different and the amount of units and effects they contain are different. For this reason, it is beneficial to have these applications performed by experienced people
in this field.
The commercial bottle of the wrinkle treatment brand is a 100-unit bottle. And when one bottle is used for facial area wrinkles (forehead, between the eyebrows and crow's feet), an average of 46-50 units is sufficient for a patient. So, one bottle of
wrinkle treatment brand is only available in sufficient dosage for 2 people.
But unfortunately; There are many places that dilute it more than necessary and apply wrinkle treatment to more than 2 people and at a much cheaper price than it should normally be. In this
case, the effect of wrinkle treatment lasts much less than 3 months or has no effect at all.
Although very rare, in some patients, the body may produce antibodies against wrinkle treatment and for this reason, even if the normal
dose is administered. Wrinkle treatment does not produce the desired effect. When I encounter such patients, after looking at and evaluating the before and after photos together, I prefer wrinkle treatment methods that can be used other than wrinkle treatment.
I apply wrinkle treatment.
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