What is recurrent pregnancy loss?
If there are two or more consecutive pregnancy losses, there is 'recurrent pregnancy loss'. If there are three consecutive losses, it requires examination.
What is the rate of recurrent pregnancy loss?
In a very small number of women (1%)
What is the most common cause of recurrent pregnancy loss?
About 60% of miscarriages occur only in that pregnancy, that embryo, fertilization. It develops due to having an abnormal number of chromosomes. This situation only occurs by chance and is not due to any medical problem. However, the incidence increases in pregnancies with advanced maternal age.
Are there any other genetic problems associated with recurrent pregnancy loss?
Very In a small group, there is a condition called 'translocation', in which a piece of a chromosome from one partner is transferred to another. People with this condition often have no physical findings or complaints. However, some of the sex cells will have abnormal chromosomes. If the embryo has too little or too much genetic material, it often results in miscarriage.
Do problems with reproductive organs cause recurrent pregnancy loss?
Some congenital problems of the uterus are associated with recurrent pregnancy loss. The most common of these is septa (partition) in the uterus. In this case, the uterine cavity is partially divided into two by a wall structure.
A condition called Asherman syndrome, in which there are adhesions in the intrauterine tissue, may also be the cause of miscarriage. Massive growths of the uterus and lining of the uterus, called myomas or polyps, can sometimes be the cause.
Do medical problems increase the risk of recurrent pregnancy loss?
The risk of recurrent pregnancy loss increases in women with certain medical problems. In an autoimmune disease called antiphospholipid syndrome (APS), the body's defense system mistakenly attacks certain clotting factors. APS is associated with recurrent pregnancy loss and stillbirth. Another responsible condition is diabetes. The rate of pregnancy loss is high, especially in poorly controlled blood sugar. Recurrent pregnancy loss in a condition called polycystic ovary syndrome It has been associated with �.
Can a cause always be found in cases of recurrent pregnancy loss?
50–75% of these cases occur. No reason can be found in it. Although there are clues about possible causes, a complete explanation may not be found.
What examinations are performed in patients with recurrent pregnancy loss?
First, a detailed medical CV and family history are questioned. A complete physical examination and gynecological examination are performed. If there is a suspicion of a problem in the immune system, a blood test may be requested. Again, genetic examination may be necessary for genetic reasons. Sometimes imaging methods are needed.
What can be done if a chromosome translocation is detected?
In this case, genetic counseling is required. The result of your genetic examination will clarify the situation. Sometimes an examination called 'preimplantation genetics' is required before in vitro fertilization. Before the egg fertilized by in vitro fertilization is given to the mother, genetic analysis is performed. Embryos with a sound genetic structure and without any genetic translocations detected in you are transferred.
How can problems related to reproductive organs be treated?
Some In some cases, corrective surgery is possible. For example, surgery is performed for the intrauterine compartment (septum).
Is there a treatment for antiphospholipid syndrome?
In this case, blood diluting therapy, such as heparin, is sometimes used together with low-dose aspirin throughout pregnancy and postpartum.
What is the pregnancy rate in patients with recurrent pregnancy loss for whom no underlying explanatory cause can be found?
65% of these people have a child as a result of successful pregnancy.
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