Poor diet is associated with80%of colorectal cancer cases, but the exact pathways how diet causes cancer are not known.
In a newly published study, Cleveland Clinic researchers found that high-fat They identified a specific molecular pathway that links a diet to tumor growth in the colon.
The experiment showed that cancer cell growth in the colon was increased by a high-fat, western diet.
Blocking the JAK2-STAT3 cellular signaling pathway is known to promote tumor growth; thus increasing cancer stem cell growth caused by a high-fat diet.
Colorectal canceris the third most common cancer in the United States, with up to 130,000 cases reported annually. The disease occurs as a result of a combination of various genetic, epigenetic and environmental causes, such as diet.
We know the impact of diet on colorectal cancer, but these new findings make the link between high fat intake and colon cancer specific. demonstrates it for the first time in a molecular way. We can leverage this knowledge to develop new treatments to prevent and reduce the adverse effects of a high-fat diet on colon cancer risk.
These findings provide a new way of regulating cancerous stem cells and counteract environmental influences such as diet. It provides insight into how cancer stem cell populations may change in advanced cancers.
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