NEW CAUSE OF HIGH PLASMA TRIGLYCERIDES HAS BEEN DISCOVERED
Hypertriglyceridemia is a disorder of lipid metabolism that develops as a result of excessive synthesis, defective processing and clearance, or the combined effects of both. Dietary triglycerides are absorbed from the small intestine and secreted into the lymphatic system. Although most of the triglycerides in the blood are absorbed from the small intestine, the liver also produces some triglycerides and releases them into the blood.
Hypertriglyceridemia has been determined to be a risk factor in itself for the development of CVD, especially recently, and has also been found to be acute for years. Knowing that it plays an important role in the development of pancreatitis and non-alcoholic steatohepatitis (fatty liver) reveals the necessity of treatment. Hypertriglyceridemia is mostly caused by uncontrolled diabetes, uncontrolled sugary foods, high fructose intake and obesity. High plasma triglyceride levels can also be caused by mutations in various genes that regulate triglyceride metabolism. However, despite years of research and an increasing understanding of triglyceride metabolism, most cases of hypertriglyceridemia are not fully understood.
We always advise individuals with high triglycerides to diet, exercise, and avoid high-fat foods. However, this did not have any effect on some patients and the reason was not revealed. In a study conducted by the University of California, researchers argue that a syndrome called "GPIHBP1 autoantibody syndrome" is a significant advance in hypertriglyceridemia.
Triglycerides in the bloodstream, found in the capillaries. It is broken down by enzymes called lipoprotein lipase. However, it has been observed that autoantibodies againstGPIHBP1 prevent the digestion of triglyceride by blocking the activity of triglyceride-degrading(digesting)lipoprotein lipase.
Scientists have identified 6 people with autoantibodies against GPIHBP, and one of these people became pregnant. These harmful autoantibodies passed through the placenta of the pregnant person and formed in the baby and entered the baby's circulation. As a result, the baby developed severe triglyceride elevation (hypertriglyceridemia). With the disappearance of the mother's harmful autoantibodies, the baby's triglyceride elevation returned to normal.
Researchers discovered the GPIHBP1 autoantibody. More research will be needed to define the frequency of the syndrome and how it might be treated, but immunosuppressive drugs may help reduce autoantibodies and lower plasma triglyceride levels, they said.
The deputy chief of atherothrombosis and coronary artery disease at the National Heart, Lung, and Blood Institute chief, dr. "Not only have the researchers discovered a new disease, their findings suggest that the disease is treatable," said Michelle Olive. It is an excellent example of how it can lead to scientific developments with its clinical effects." They said.
Read: 0
