PGD (Preimplantation Genetic Diagnosis) has a different usage area than PGS. With PGD, abnormalities called single gene diseases are screened.
What is Preimplantation Genetic Diagnosis?
PGD is especially single gene disease (cystic fibrosis, thalassemia/sickle cell anemia, hemophilia, balanced structural chromosome disorder). It is applied to couples who are at risk. If this sperm and egg are fertilized, it can cause a chromosomally abnormal embryo to form. Such a situation that occurs in the embryo may cause the death of the embryo, miscarriage or the birth of a child with serious medical problems.
Who Should Have Preimplantation Genetic Diagnosis (PGD)?
detection of a single gene disease carrier that is likely to be passed on to the baby (rearranged structural chromosome carrier; translocation, inversion, deletion). .
Some points you need to be prepared for with the Preimplantation Genetic Diagnosis (PGD) method;
- Some technical problems may occur during the preparation or biopsy phase.
- If a successful IVF and PGD procedure is performed Even after the transfer, pregnancy may not occur.
- Since only a certain number of chromosomes can be controlled, not all chromosomal and genetic abnormalities can be diagnosed with PGD.
How and When Should Preimplantation Genetic Screening and Diagnosis (PGS and PGD) be done?
After fertilization The embryo is followed for 3 days in the culture system in the laboratory environment until it reaches the 8-10 cell stage. One or two cells are taken from these 3-day-old embryos by biopsy and certain chromosomal tests are performed. PGS/PGD procedure is applied to the chromosomes (13, 16, 18, 21, 22, X and Y) where chromosomal anomaly is most common. Embryos that are not seen as malignant are transferred to the uterus (uterus) of the mother.
What are the Advantages of Preimplantation Genetic Screening and Diagnosis (PGS and PGD)?
Success in pregnancy by selecting the best healthy embryo to be transferred It contributes to increase the rate of miscarriage.
It is aimed to reduce the risk of miscarriage. It is ensured that the embryo to be frozen or screened is decided.
Read: 4
