Mesenchymal Stem Cell is an adult type stem cell found in the connective tissue of cells. These cells have the ability to pass from the tissues they are in the body to the damaged tissues and to differentiate in any environment.
What are the Characteristics of Mesenchymal Stem Cells?
These stem cells have the ability to differentiate into every tissue. They differ in appearance in lung, stomach and bone tissue. The reason for this is the different conditions in the environment.
Mesenchymal stem cell not only repairs the damage in its own tissue, but also transfers to the other tissue in case of damage to another tissue and provides repair.
What are the Advantages of Mesenchymal Stem Cells?
- Because they are of connective tissue origin, they can contribute to the development and function of related tissue cells.
- It has the ability to differentiate.
- It can differentiate into cells such as muscle, fat, bone, cartilage, tendon, ligament, which are the connective tissue cells from which it originates,
- It can differentiate into other tissue cells (neuron, hepatic, pancreatic cell). They also have the ability to differentiate (transdifferentiation). They can contribute.
- They can reach the damaged tissue thanks to their migration properties.
- They are mostly immunosuppressive/non-immunogenic, that is, they do not stimulate the immune system. In this way, they are accepted by the body when they are injected. .
- The most important disadvantage of these cells, which have been shown to have many advantages in terms of clinical use, is that they need to be reproduced in cultures for weeks in a special laboratory environment due to their very low number. This requires serious technology, infrastructure, experience, and the cost is high.
MSCs obtained from Wharton's Jelly found in fat (adipose) tissue, bone marrow or umbilical cord and cultured in our GMP standard laboratories in our center and made ready for application to the patient, have strong regenerative effects, new vessel forming capacities and immune It has a wide range of applications thanks to its suppressive/regulatory effects on the system.
MSCs are used in soft tissue defects, non-healing chronic wounds (such as diabetic wounds), the treatment of burn scars, peripheral vascular diseases (such as Burger, ischemic foot), a tumor tissue It is widely used in peri-tissue damage after mastectomy (such as breast filling after mastectomy), face filling, hand and facial rejuvenation (wrinkle removal). It is used in the prophylaxis and treatment of GVHD.
????Where Are Mesenchymal Stem Cells Found?
Mesenchymal Stem Cells are extensively used in the umbilical cord, adipose tissue, bone marrow, dental pulp, placenta and amnion. found in tissues such as fluid.
The clinical usage areas of Mesenchymal Stem Cells are;
MSCs are used in the treatment of diseases caused by damage to tissues and organs that develop from mesenchymal cells such as bone, cartilage, muscle and adipose tissue. Apart from mesenchymal tissues, they have the ability to differentiate (transdifferentiate) into cells of neuron, hepatic and pancreatic tissues. Because of its strong immunosuppressive effects, it is used in the prophylaxis and treatment of acute Graft versus Host Disease after allogeneic stem cell transplantation. It is used in the treatment of autoimmune diseases such as Autoimmune Encephalomyelitis, Osteogenesis Imperfecta, Rheumatoid Arthritis, Crohn's Disease, Systemic Lupus, Diabetes, Multiple Sclerosis. “Clinical trials for the treatment of autoimmune diseases such as Autoimmune Encephalomyelitis, Osteogenesis Imperfecta, Rheumatoid Arthritis, Crohn's Disease, Systemic Lupus, Diabetes, Multiple Sclerosis also yield promising results.
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