Celiac disease develops in individuals with a genetic predisposition as a result of sensitivity to the water-insoluble protein called gluten, which is found in grains such as wheat, barley and rye. An autoimmune enteropathy develops as a result of genetic predisposition, contact with specific environmental factors and immunological mechanisms. The disease mainly affects the proximal small intestine, but different organs/systems may also be affected. The disease can occur at any age after the addition of grains to the diet.
Celiac disease can occur at different ages. It may appear in childhood or may manifest itself later in life. The very mild progression of the disease and confusion of symptoms with different disorders may cause the diagnosis to be made at an older age. Celiac disease, the most common symptom of which is growth retardation in childhood; p>
· Gas complaints and abnormal stools
· Vomiting, weakness and loss of appetite
· Canker sores in the mouth
· Joint and bone pain
· Vomiting, weakness and loss of appetite
· Canker sores in the mouth
· Joint and bone pain
p>· Irritability
· It manifests itself with symptoms such as itching and rashes on the skin.
Symptoms of celiac disease may also bring to mind different diseases. In order to make the correct diagnosis, some special blood tests, endoscopy and tissue samples taken must be examined by pathology.
If there are symptoms such as anemia, osteoporosis, infertility or seizure
should be investigated for gluten. While the patient has been on a gluten-free diet for a while, one or more antibody tests may be requested. Thus, it is confirmed that antibody levels have decreased, the diet has resolved the complaints, and the damage to the layer covering the inside of the intestine has been corrected. If the patient's symptoms have not resolved, celiac disease tests may be requested to check compliance with the diet and to help the doctor and the patient investigate hidden gluten sources in the diet or the causes of persistent complaints. Patients who have a close relative with celiac disease and are asymptomatic can be tested. However, now, celiac disease is being used as a screening test for the general public. It is not recommended to perform GI tests. Anti-ttg antibodies, IgA, Total IgA, Anti-ttg antibodies, IgG, Anti-gliadin antibodies (AGA), IgG Tests are the most important tests in the diagnosis of celiac.
Intestinal biopsy after positive or indeterminate celiac disease tests. makes. A biopsy is performed for a definitive diagnosis of celiac disease.
If a person diagnosed with celiac disease removes gluten from his diet, autoantibody levels should decrease. If these levels do not decrease and the complaints do not decrease, either there is gluten in the diet that has not been eliminated (gluten is often found in unexpected foods. For example: salads, cough syrups, adhesive tape used on envelopes), or the patient may have celiac disease, which is rare and does not respond to changes in diet. When celiac disease tests are used to monitor disease progression, rising autoantibody levels indicate some noncompliance with the gluten-free diet.
Celiac disease tests may be negative if the person being tested has not consumed any gluten-containing foods before the test (although a negative result requires several months of a gluten-free diet). If the doctor still suspects celiac disease, he or she may prescribe gluten. The patient is asked to add gluten to his diet for a few weeks or months to see if the symptoms return. Meanwhile, celiac tests may be repeated or a biopsy may be performed to check whether there is villus atrophy (damage to the hairy protrusions in the intestines).
Although celiac disease is relatively common, most patients are unaware of their disease. This is partly due to the fact that symptoms vary. Although intestinal damage is present in tissue biopsy samples, symptoms may be mild or absent. Since these symptoms may be due to various diseases, the diagnosis of celiac disease can sometimes be missed or delayed for years.
Read: 0
