It belongs to the group of inflammatory rheumatic diseases of autoimmune origin. The main symptom of the disease is dryness. Dry mouth, dry eyes, dry skin, vaginal dryness… etc. It was named after the Swedish ophthalmologist Henrik Sjögren, who first described it. Although it primarily affects the lacrimal glands, it can also involve systems such as the lungs, kidneys, musculoskeletal system... It can be seen together with other autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and scleroderma (secondary Sjögren's syndrome), or it can be seen alone (primary Sjögren's syndrome).
How does Sjögren's syndrome develop?
As with all autoimmune diseases, there is a genetic basis. However, there is no isolated gene identified. The basic mechanism is the development of organ tissue damage by the immune system cells, which are the defense system of our body, primarily perceiving the gland cells as foreign and waging both cellular and humoral (secretory) war against these cells, formation of autoantibodies, antigen-antibody complexes and initiating the inflammatory response.
In the clinic, it first manifests itself with a decrease in tears, a feeling of discomfort as if sand has gotten into the eye, a dry mouth, a frequent desire to drink water while talking or eating, and prodromal findings such as weakness, fatigue, loss of appetite, and weight loss accompany the picture. Pain and morning stiffness begin to appear in the joints. After a while, the skin dries and cracks, and sexual intercourse becomes painful due to vaginal dryness. It is progressive if left untreated. Lungs, kidneys, nerves, thyroid gland, endocrine system, liver, gallbladder and brain are affected, and loss of function occurs.
It is generally more common in women than men. Although it is a disease especially in the middle age group, it can be seen at any age.
How is the diagnosis made in Sjögren's syndrome?
Detection of dryness is very important in making the diagnosis. It is important. Often, ophthalmologists can detect dry eyes and guide patients. Dry eye is detected by tear breakup time or Schirmer test. The presence of sublingual saliva during a saliva test, sialogram, or physical examination is significant in making the diagnosis. If necessary, parotid ultrasonography and MRI may be used to differentiate from other pathologies of the parotid gland.
Positive serological tests such as ANA, anti Ro and anti La are also among the diagnostic evaluations. Again, blood count to screen for organ system involvement, acute phase response, sedimentation rate and CRP to evaluate biochemistry and inflammation may be requested. One of the most important evaluation methods is to pathologically demonstrate the severity of inflammation by performing an excisional biopsy of the minor salivary glands.
Treatment of Sjögren's Syndrome
Treatment is aimed at both relieving the symptoms and improving the patient's quality of life and preventing the progression of the disease and organ damage by stopping inflammation.
Since saliva is important for our oral and dental health, when the quality of saliva deteriorates, oral ulcers, fungal infections and Tooth decay is common. Good oral care and dentist check-up are important. It is also recommended to drink plenty of water, gargle, and chew sugar-free gum. Tablets containing the salivary stimulant pilocarpine can be used. Artificial tears should be used regularly for dry eyes.
Using moisturizers regularly for dry skin prevents skin infections. It is beneficial to change laundry and bath towels frequently, take frequent baths, and apply moisturizer to the whole body while the skin is slightly damp. Suitable preparations are also available for vaginal dryness. In addition, as with all autoimmune diseases, it is useful to use sunscreen. It is recommended to use room humidifiers and incense burners to moisturize the bronchial mucosa. It is also important to exercise regularly.
Apart from these, steroids and disease-regulating anti-rheumatic agents-DMARDs, which are used in the treatment of all rheumatic diseases, are also used in the treatment of this disease
>It belongs to the group of inflammatory rheumatic diseases of autoimmune origin. The main symptom of the disease is dryness. Dry mouth, dry eyes, dry skin, vaginal dryness… etc. It was named after the Swedish ophthalmologist Henrik Sjögren, who first described it. Although it primarily affects the lacrimal glands, it can also involve systems such as the lungs, kidneys, musculoskeletal system... It can be seen with other autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and scleroderma (secondary Sjögren's syndrome). u), can also be seen alone (primary Sjögren's syndrome).
How does Sjögren's syndrome develop?
As with all autoimmune diseases, there is a genetic basis. However, there is no isolated gene identified. The basic mechanism is the development of organ tissue damage by the immune system cells, which are the defense system of our body, primarily perceiving the gland cells as foreign and waging both cellular and humoral (secretory) war against these cells, formation of autoantibodies, antigen-antibody complexes and initiating the inflammatory response.
In the clinic, it first manifests itself with a decrease in tears, a feeling of discomfort as if sand has gotten into the eye, a dry mouth, a frequent desire to drink water while talking or eating, and prodromal findings such as weakness, fatigue, loss of appetite, and weight loss accompany the picture. Pain and morning stiffness begin to appear in the joints. After a while, the skin dries and cracks, and sexual intercourse becomes painful due to vaginal dryness. It is progressive if left untreated. Lungs, kidneys, nerves, thyroid gland, endocrine system, liver, gallbladder and brain are affected, and loss of function occurs.
It is generally more common in women than men. Although it is especially a disease of the middle age group, it can be seen at any age.
How is Sjögren's syndrome diagnosed?
Detection of dryness is very important in making a diagnosis. Often, ophthalmologists can detect dry eyes and guide patients. Dry eye is detected by tear breakup time or Schirmer test. The presence of sublingual saliva during a saliva test, sialogram, or physical examination is significant in making the diagnosis. If necessary, parotid ultrasonography and MRI may be requested to distinguish it from other pathologies of the parotid gland.
Positive ANA, anti-Ro and anti-La serological tests are also among the diagnostic evaluations. Again, blood count to screen for organ system involvement, acute phase response, sedimentation rate and CRP to evaluate biochemistry and inflammation may be requested. One of the most important evaluation methods is to pathologically demonstrate the severity of inflammation by performing an excisional biopsy of the minor salivary glands.
Sjögren's Send. rum treatment
Treatment is aimed at both relieving the symptoms and improving the patient's quality of life and preventing the progression of the disease and organ damage by stopping inflammation.
Saliva is used in the mouth and mouth. Since saliva quality is important for our dental health, oral ulcers, fungal infections and tooth decay are common when saliva quality deteriorates. Good oral care and dentist check-up are important. It is also recommended to drink plenty of water, gargle, and chew sugar-free gum. Tablets containing the salivary stimulant pilocarpine can be used. Artificial tears should be used regularly for dry eyes.
Using moisturizers regularly for dry skin prevents skin infections. It is beneficial to change laundry and bath towels frequently, take frequent baths, and apply moisturizer to the whole body while the skin is slightly damp. Suitable preparations are also available for vaginal dryness. In addition, as with all autoimmune diseases, it is useful to use sunscreen. It is recommended to use room humidifiers and incense burners to moisturize the bronchial mucosa. It is also important to exercise regularly.
Apart from these, steroids and disease-regulating anti-rheumatic agents-DMARDs, which are used in the treatment of all rheumatic diseases, are also used in the treatment of this disease
>It belongs to the group of inflammatory rheumatic diseases of autoimmune origin. The main symptom of the disease is dryness. Dry mouth, dry eyes, dry skin, vaginal dryness… etc. It was named after the Swedish ophthalmologist Henrik Sjögren, who first described it. Although it primarily affects the lacrimal glands, it can also involve systems such as the lungs, kidneys, musculoskeletal system... It can be seen together with other autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and scleroderma (secondary Sjögren's syndrome), or it can be seen alone (primary Sjögren's syndrome).
Sjögren's. How does the syndrome develop?
As with all autoimmune diseases, there is a genetic basis. However, there is no isolated gene identified. The immune system cells, which are the defense system of our body, primarily perceive the gland cells as foreign and wage both cellular and humoral (secretory) war against these cells, autoantibodies. The basic mechanism is the development of organ tissue damage by the formation of antigen-antibody complexes and initiating the inflammatory response.
In the clinic, the first thing that is seen is a decrease in tears, a feeling of discomfort as if there is sand in the eye, a dry mouth, a desire to drink water frequently while talking or eating something. It manifests itself and is accompanied by prodromal symptoms such as weakness, fatigue, loss of appetite, and weight loss. Pain and morning stiffness begin to appear in the joints. After a while, the skin dries and cracks, and sexual intercourse becomes painful due to vaginal dryness. It is progressive if left untreated. Lungs, kidneys, nerves, thyroid gland, endocrine system, liver, gallbladder and brain are affected, and loss of function occurs.
It is generally more common in women than men. Although it is especially a disease of the middle age group, it can be seen at any age.
How is Sjögren's syndrome diagnosed?
Detection of dryness is very important in making a diagnosis. Often, ophthalmologists can detect dry eyes and guide patients. Dry eye is detected by tear breakup time or Schirmer test. The presence of sublingual saliva during a saliva test, sialogram, or physical examination is significant in making the diagnosis. If necessary, parotid ultrasonography and MRI may be requested to distinguish it from other pathologies of the parotid gland.
Positive ANA, anti-Ro and anti-La serological tests are also among the diagnostic evaluations. Again, blood count to screen for organ system involvement, acute phase response, sedimentation rate and CRP to evaluate biochemistry and inflammation may be requested. One of the most important evaluation methods is to pathologically demonstrate the severity of inflammation by performing an excisional biopsy of the minor salivary glands.
Treatment of Sjögren's Syndrome
Treatment is aimed at both relieving the symptoms and improving the patient's quality of life and preventing the progression of the disease and organ damage by stopping inflammation.
Since saliva is important for our oral and dental health, when the quality of saliva deteriorates, oral ulcers, fungal infections and Tooth decay is common. Good oral care and dentist check-up are important. Also drink plenty of water
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