Emergency intervention may be necessary most of the time in diseases related to the heart and vascular system. Some biochemical parameters examined in the blood circulation of the person are diagnostically important in chest pain and other cardiac symptoms.
What is Troponin T?
Troponin is among the biochemical markers that can indicate changes related to the heart.
Troponin is an important protein that plays an activity-regulating role in cardiac muscle cells. With the binding of calcium to this protein, some changes occur in its structure, and thanks to these changes, actin and myosin strands move and contraction of the heart muscle cell occurs.
Troponin, which is a complex protein structure, consists of 3 sub-troponin groups. Troponin C (TnC), Troponin I (TnI) and troponin T (TntT) come together to form troponin protein. is an abbreviation. Sometimes, this troponin subunit can be perceived as "troponin 1" as a result of confusing the letter "I" with the Roman numerals "1". Therefore, the answer to the question of what is troponin 1 can be answered, "troponin 1 actually defines troponin I." below the acceptable level and troponin tests may be inconclusive. If normal values are detected in troponin tests performed within 12 hours from the onset of pain in people who apply to health institutions with heart-related complaints such as chest pain, the probability of the underlying cause of chest pain being a heart attack decreases.
The protein level measured by the troponin test is per milliliter. united in nanograms. Whether the measured troponin level is abnormal or not is decided by evaluating the percentile, and the positive troponin value above the 99th percentile is important in that it indicates damage to the heart cells of the person and that the troponin contained in it passes into the blood circulation. In contrast to men, women may have a heart disease in the background in case of low troponin. It should be considered.
Heart attack is a fatal disease that occurs after the coronary vessels, which are responsible for feeding the heart and oxygen support, are blocked for various reasons. After atherosclerosis, the oxygen necessary for the contraction of the heart muscle cannot reach the cells, and this may result in irreversible damage to the cells in the affected area. The membranes of the heart cells, which are deprived of nutrition and oxygen, break down and the structures inside the cell pass into the blood circulation. Troponin, which is among the substances that pass into the bloodstream with this mechanism, begins to rise within a period of approximately 2-3 hours following the onset of chest pain. The peak level of troponin occurs within a time frame of 12-48 hours. The troponin level, which rises and peaks, decreases towards its normal level 4 to 10 days after this process. . In the diagnostic stages, taking the patient's history is especially important in terms of questioning the symptoms that may be associated with a heart attack. Pain radiating to the neck, jaw, shoulder and arm, excessive sweating, drowsiness, nausea, weakness and shortness of breath are among the findings other than chest pain, which indicate that the person may be having a heart attack. There are many conditions that can cause it to be detected as:
Myocarditis (inflammation of the heart muscle) Inflammation of the heart muscle tissue, called myocardium, for various reasons is expressed as myocarditis. Inflammation of the heart muscle prevents this tissue from performing its functions fully and causes various problems with blood pumping. Diseases caused by viruses do not cause myocarditis development. comes first among them. Myocarditis may develop due to factors such as coxsackie virus b, hhv 6 and parvovirus b19. Inflammation of the heart muscle may occur due to various bacteria, fungi and parasites apart from viruses. Apart from infectious diseases, care should be taken as myocarditis may develop during the course of autoimmune diseases such as rheumatoid arthritis and lupus, in which the immune system damages its own tissues and cells. Inflammation of this structure is usually caused by bacteria. Hearing a murmur during heart work after the development of endocarditis is an important physical examination finding. Apart from the murmur, symptoms such as fever, chills and night sweats, muscle and joint pains, coughing or shortness of breath may occur. Insufficiency may affect only the left or right part of the heart, or there are cases where both sides are affected at the same time. The symptoms that occur in patients with sudden onset heart failure may regress in a short time. If heart failure is a chronic event that has been going on for a long time, the complaints it causes may tend to continue without any improvement. Extreme fatigue, sudden and unexplained weight gain, persistent cough, palpitations, abdominal swelling and shortness of breath are among the symptoms that may occur after the development of heart failure. In the majority of cases, patients' heart weakens and their function of pumping blood to the rest of the body is adversely affected. The consequences of this disease include various conditions such as irregular heartbeats, heart failure and valve problems. Cardiomyopathy is divided into different subgroups. Dilated cardiomyopathy is the most common form of cardiomyopathy and is characterized by thinning of the heart muscle and enlargement of the heart chambers. Hypertrophic, another form of cardiomyopathy In cardiomyopathy, the heart tissues are thickened and this thickening can reach dimensions that prevent the flow of blood within the cavities of the heart. Hypertrophic cardiomyopathy is a genetic disease with a familial inheritance. After the blockage, the lung tissue in the affected area is destroyed and the oxygen level in the blood circulation decreases. Pulmonary embolism can be fatal if the clot reaching the lung is multiple or in large sizes. Conditions such as hip and leg fractures, cancer, the presence of people in the family with pulmonary embolism, major surgery, heart attack and obesity are among the accepted risk factors for the development of pulmonary embolism.
These reasons. Elevated troponin levels may also occur due to some diseases other than:
- Diabetes
- Hypothyroidism
- Stroke
- Internal bleeding
- Kidney diseases
- Pericarditis (inflammation of the lining of the heart)
- After excessive exercise
- Burns
- Severe like sepsis progressive infectious diseases
- After the use of certain drugs
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