In patients withcancer in the head and neck region, up to 30%, without anyclinicalorradiological symptoms. Hidden metastases may be found at high rates. It is not possible to know exactly which patients will be included in this 30% at the time of diagnosis. Treating all patients as if they had spread in the neck would mean that 70% of the patients would be treated more severely than necessary and would therefore be exposed to more complications. According to the study of Goodyear PWA and colleagues published in the journal Clinical Otolaryngology, analysis of tumor tissue for protein content may shed light on this problem in the future. According to the results obtained by the researchers on a limited number of samples, an increase in heat shock protein 90, T complex protein 1 gamma, Bromodomain PHD finger protein 3 and lactate dehyrogenase A proteins and a decrease in thymidine phosphorylase protein were detected in patients with longitudinal spread.
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