Cyanocobalamin is another name for vitamin B12.
It causes the formation of red blood cells in the body and maintains the healthy functioning of the central nervous system. It dissolves in water.
It passes into the boiling water of the foods. Meats are the best sources. Lean meats are slightly more rich in B group vitamins than fatty meats. It is also found in milk and dairy products and eggs. Offal is a rich source.
Assessing clinical manifestations of B12 deficiency is often difficult. In case of B12 deficiency, macrocytic anemia (red blood cells being larger than normal), peripheral neuropathy, spinal cord deterioration are rarely seen. On the other hand, they are other deficiency symptoms such as fatigue, weakness, malaise, dizziness, and cognitive insufficiency.
All these symptoms overlap with the complaints of old age. Vitamin B12 deficiency is determined by a decrease in blood vit B12 values. In addition to vitamin B12 deficiency, folate deficiency is also observed in elderly people, and homocysteine levels increase in people with folate deficiency.
Increased homocysteine in the blood causes complex changes in the vessel wall. Experimental studies show that the increase in homocysteine paves the way for the development of atherosclerosis (hardening of the arteries). Clot accumulation and intimal damage develop on the inner surface of the vessel. It impairs tissue repair and causes tissue damage. It has important contributions to the formation of inflammation in the vessels. The increase of homocysteine in the blood causes toxicity by stopping the development of the inner surface of the vessel, preventing cell regeneration, and causing toxicity.
The production of fat is disrupted. The release of fat components increases. Fat is mostly responsible for atherosclerosis disease. Normal total homocysteine levels can be evaluated as 5-15 mmol/L in fasting state, 15-30mmol/L moderate 30-100mmol/L intermediate, over 100 mmol severe.
Causes of homocysteine elevation in blood:
– Genetic disorders in homocysteine metabolism
-Nutrition disorders; Vitamin B12, B6, and folate deficiency cause homocysteine to rise in the blood.
-In chronic kidney failure
-Hypothyroidism (underactive thyroid gland)
-Chronic gastritis-Helicobacter pylori (microorgan that causes gastritis) An increase in homocysteine levels has been reported due to folate deficiency in nysma). levels were found to be high.
-Theophylline (asthma medicine) and smoking(2)
The main function of vitamin B12 is to support the production of DNA, which is necessary for cell division or proliferation, by providing the use of folic acid. Another task is to take part in the structure of the brain and surrounding nerves.In addition, vitamin B12, together with folate, is involved in the conversion of homocysteine to methionine. Therefore, an increase in homocysteine levels is observed in folate and vitamin B12 deficiency. shows that it is associated with cardiovascular disease.
In addition, it is known that factors such as dietary habits and lifestyle (smoking, coffee and exercise) can change homocysteine levels.
B12 and folic acid deficiency in blood homocysteine. concentrations increase and this creates a toxic (poison) effect for nerve cells. Therefore, individuals with Alzheimer's should pay attention to their B12 v2 folic acid intake.
Have your vitamin B12 checked. If it is missing, take a supplement under the control of a doctor.
Have a good week.
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