It is not always possible to achieve successful results in in vitro fertilization attempts. The most important factor to consider when evaluating success rates in in vitro fertilization is the woman's age. Failure rates increase as women age. The most important reason for this is that genetic disorders are more common in eggs as age progresses. However, even in young couples, although everything seems normal, pregnancy may not occur even with in vitro fertilization treatment. At this point, although suggestions such as 'Fate, Luck, Destiny' can be made because medicine cannot explain everything, the suggestion of medical scientists is to try again. The most important thing to consider here is to learn from the first attempt and carefully examine the couple's response in the first attempt and try to make them more successful in the second attempt. In the new trial, the effects of the first attempt on egg development and embryo development are evaluated in detail.
In Vitro Fertilization Failure
It is the situation where pregnancy cannot be achieved in 3 or more in vitro fertilization applications despite the transfer of good quality embryos (10 or more). In vitro fertilization failure may be caused by the following situations.
1) Hydrosalpinx (fluid accumulation in the tubes) should be investigated. In the presence of hydrosalpinx, the tube should be removed laparoscopically as a preparation before in vitro fertilization. If this is not possible due to intra-abdominal adhesions, blockage should be provided at the tube-uterus junction.
2) Intrauterine evaluation. It should be shown that there is no problem in the uterus by ultrasonography, uterine tube film (HSG), and, if necessary, hysteroscopy.
3) Myoma. Myomas (submucous) that have grown into the uterus are removed hysteroscopically before in vitro fertilization. The effects of fibroids that do not put pressure on the uterus on the success of in vitro fertilization are controversial. However, in some studies, it has been reported that myomas larger than 4-5 cm in diameter may have negative effects on pregnancy rates in in vitro fertilization, even if they do not put pressure on the inner layer of the uterus.
4) The applied treatment protocols are reviewed. Dosage and embryo quality of the protocols are affected. and its effects on the inner wall of the uterus are reviewed. Previous treatment protocols and the results obtained are examined in detail and clues are sought in choosing a new approach.
5)Checking clotting factors in women
6)Genetic tests of the expectant mother and father
7)Revealing the detailed endocrinological and metabolic status of the woman.
8)New individualizing the treatment option as much as possible
9)Application of laboratory and clinically proven support methods
10)Maximum attention to the embryo transfer process and arranging post-transfer support treatments
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